| Papers [1-14] of 100 :: [Page 1 of 8] | | Go to page : 1 2 3 4 5 6 7 8 —> | Search results on "NEWBORN SCREENING SICKLE CELL DISEASE": |
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Newborn Screening for Sickle Cell Disease, 2008.
This paper focuses on the importance of neonatal screening for sickle cell disease.
1,458 words (approx. 5.8 pages), 8 sources, APA, £ 33.95
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Abstract
The paper relates that while researchers and the medical field are very concerned about this disease, nurses, other health providers and governments, Ontario's in particular, are not aware of the nature of sickle cell disease. The paper explains the factors that prevent individuals and groups from focusing on sickle cell disease as a significant issue. The paper discusses how neonatal screening identifies people at risk and allows for preventive measures to be taken. The paper shows how this is cost-effective because it will result in high savings for the health care system later on. The paper discusses how advocacy and a major program of health promotion could promote this issue of neonatal screening.
From the Paper
"In comparison with the United States, Canada is inconsistent in relation to newborn screening. Ontario especially is far behind other countries in this type of screening (Eggertson, 2005). Pediatricians, physicians, along with experts in sickle cell disease and thalessemia, are asking for a comprehensive program for newborn screening that will include the 29 treatable conditions recommended by the U.S. advisory committee. This is one area in which health professionals as a whole have failed to lobby, even though it involves primary prevention. Meanwhile researchers are struggling to find assessment tools to identify high risks for sickle cell disease. The issue here is that while researchers and the medical field are very concerned about this disease, nurses and other health providers along with the government - especially the Ontario government - are not aware of the nature of sickle cell disease."
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Sickle Cell Disease, 2006.
A discussion of the pathology and treatment of sickle cell disease.
2,650 words (approx. 10.6 pages), 7 sources, MLA, £ 54.95
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Abstract
This paper presents a detailed overview of sickle cell disease, an inherited disease of the red blood cells, which is present from birth. The paper begins with a brief discussion of the history of the disease, including its discovery. Next the paper investigates the pathophysiological aspects of the disease, presenting the information in easy-to-understand layman terms. The paper then discusses how sickle cell disease affects sufferers physically. Finally the paper presents and evaluates treatment options.
Outline:
Historical Perspective
Pathophysiological Basics of Sickle Cell Disease
Physical Manifestations of Sickle Cell Disease
Treatment options for Sickle Cell Disease
Conclusion
From the Paper
"Before one can speak in depth on sickle cell disease itself, one must understand the basic pathophysiology which surrounds the condition. Hemoglobin is a protein carried by red cells, which carries oxygen from the lungs for delivery to peripheral tissues. It is composed of two similar proteins, alpha and beta. It is the coordinated action of the alpha and beta globin chains which allow the oxygen transport to occur. These two chains combine to form hemoglobin. During life, except during the very first week of embryonic development, one of the globin chains in an alpha. A developing fetus also has another chain which is a gamma globin; sometimes called non-alpha is present in the fetal circulation. The gamma globin is replaced shortly after birth with the beta, which then chains with the alpha. When two alpha chains combine with two gamma chains, this is called Hemoglobin F, or the common hemoglobin of fetal circulation. Adult hemoglobin, formed of two alpha and beta chains is called Hemoglobin A. If one alpha and one non-alpha chain combine, then this two chain combination is called a dimer and it not functional enough to deliver oxygen to tissues."
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Sickle Cell Disease, 2002.
This paper deals with sickle-cell disease (SCD, also known as sickle cell anemia) from a genetic point of view.
1,400 words (approx. 5.6 pages), 8 sources, £ 36.95
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Abstract
This paper discusses that the disease and its genetic trait do not conform well to the traditional model of genetic inheritance, which required that the medical establishment rethink its ideas about genetic concepts like "dominant" and "recessive". The author points out that it often occurs in areas rife with malaria, and may be linked to an increased protection from severe malaria. The paper includes: symptoms of SCD, treatments and gene therapies, and demographics.
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Sickle Cell Pain Management, 2005.
Literature review for the management of sickle cell disease pain.
3,150 words (approx. 12.6 pages), 15 sources, APA, £ 77.95
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Abstract
This paper presents an overview of Sickle Cell disease, discussing major concerns associated with the disease including that of pain management. The paper reviews a number of studies about the management of sickle cell disease pain.
From the Paper
"Sickle cell disease is common in the United States among African-Americans. Pain is a problem associated with sickle cell disease which occurs when blood vessels become clogged with sickle shaped red blood cells that are hard and sticky, preventing blood from flowing through the veins. A clogged blood vessel is called an occlusion and occlusions in blood vessels can..."
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Biochemistry and Genetics of Sickle-Cell Anemia, 2006.
Presents an overview of sickle-cell anemia, looking at current treatment of the disease, its prognosis and promising treatments on the horizon.
1,800 words (approx. 7.2 pages), 9 sources, £ 49.95
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Abstract
Sickle cell anemia is a devastatingly painful and fatal disease that strikes those of African-American heritage at a disproportionate rate. After a brief discussion on the generalities of the disease, diagnostics, treatment and prognosis, this paper examines the biochemical and genetic influences of the disease and offers suggestions for further research efforts. Advances in biochemical knowledge and technology are taking research on sickle cell anemia to the next level; however, advances in genetics are even more remarkable. This paper highlights one of the most recent and promising genetic fixes for those afflicted and at risk for sickle cell anemia.
From the Paper
"According to the National Human Genome Research Institute ("Learning About," 2005) sickle cell disease "is the most common inherited blood disorder in the United States." The disease strikes 1:12 African Americans who are parented by two disease carriers who pass on a mutated hemoglobin-Beta gene found on chromosome 11 ("Learning About," 2005). Until recently, sickle cell disease was thought to be a death sentence with most victims not living beyond 20 years of age and the rest generally not living past the age of 50 (Taher & Kazzi, 2005). With new treatments, such as hydroxyurea, victims of the sickle cell genetic mutation are not living past 50 ("Learning About," 2005). After a brief disease profile that includes a discussion of disease pathology, biochemical and genetic influences, diagnostics, treatment and prognosis. Advances in biochemical knowledge and technology are taking research on sickle cell anemia to the next level;"
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Sickle Cell Retinopathy, 2004.
A brief analysis of sickle cell retinopathy.
704 words (approx. 2.8 pages), 9 sources, MLA, £ 17.95
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Abstract
This paper discusses sickle cell disease, a genetic disorder that manifests itself in all body systems. Although some authors have questioned whether retinopathy is actually a sickle cell trait, ocular manifestations may be severe, including sudden blindness. The paper discusses the surgical treatment that is indicated once retinopathy advances to the proliferative stage and contends that several treatment options may be utilized, but should be chosen to meet the patient's medical history and disease severity.
From the Paper
"Sickle cell hemoglobinopathy encompasses a group of inherited genetic disorders, which cause erythrocytes to sickle and adversely affect multiple organ systems. The sickled erythrocytes lead to microvascular occlusion, which affects the peripheral retinal vasculature and results in retinal ischemia and development of proliferative sickle cell retinopathy. If this series of events does not stabilize or reverse, the end-stage results may be retinal infarction and/or detachment 1."
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Sickle Cell Anemia, 2008.
This paper discusses the genetic condition of sickle cell anemia.
826 words (approx. 3.3 pages), 2 sources, MLA, £ 20.95
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Abstract
In this article, the writer discusses the genetic condition of sickle cell anemia, a life-long condition that causes defective red blood cells, which form sickle cell shapes upon becoming deoxygenated, rather than maintaining the usual disc shape. The writer explains that the deformity in shape prevents the red cells from moving easily through the blood vessels as normal cells would. The sickle-shaped cells tend to form clumps in the blood vessels and prevent the healthy cells from getting through. The writer discusses symptoms and diagnosis of the disorder as well as a possible therapy that mainly focuses on relieving the symptoms associated with the condition.
Outline:
Introduction
Genetics
Mechanism
Symptoms
Diagnosis
Therapy
From the Paper
"The main problems which will put the patient at risk in sickle cell disease are the sickle cell crises. These are an issue not only to the severe pain which they cause but also due to the damage which the blockage of blood vessels can cause when they occur in or around an organ. Pulmonary complications are a particular problem for sufferers of sickle cell disease, which are caused in this manner. Bacterial infections are also a significant cause of morbidity and mortality in sickle cell sufferers as the function of the spleen is usually either compromised or entirely absent. Splenic sequestration is one of the most serious complications of sickle cell disease, in which the spleen swells and causes a significant drop in hemoglobin levels."
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Sickle Cell Crisis Patient, 2005.
A case study examination of history taking of developmental milestones for a young sickle cell crisis patient.
1,206 words (approx. 4.8 pages), 4 sources, APA, £ 28.95
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Abstract
This paper demonstrates a scenario using history-taking techniques that include culture, religion and developmental milestones of a young sickle cell crisis patient. The paper focuses on the specific information in the evaluation and includes physical milestones, gross and fine motor skills, language and social development for the patient's particular age group.
Table of Contents:
Patient History Scenario and Sickle Cell Disease
Culture and Religion
History Taking and Developmental Milestones
Conclusion
From the Paper
"The assessment of the patient is inadequate hydration and caloric intake. Damon exhibits extreme fatigue from dehydration and an inability to rest well. Triggering events that have been known to cause a sickle cell crisis and pain are: becoming overheated, dehydration, increased physical activity, and inadequate sleep and rest (Pain in sickle cell disease, n.d.). Damon experienced all those events. Damon was given fluids in the emergency room, pain medication, and instructed to participate in football practice only one time per day and not until all the pain had subsided. The parents were instructed to keep a close watch on Damon during the practices and to make sure he had the proper fluid and caloric intake, along with good rest habits."
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Sickle Cell Anemia, 2006.
An in-depth look at sickle cell anemia.
2,929 words (approx. 11.7 pages), 13 sources, MLA, £ 59.95
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Abstract
This paper reviews and discusses sickle cell anemia. According to the paper, sickle cell anemia is an inherited blood disorder characterized primarily by chronic anemia and periodic episodes of pain. Sickle cell anemia is in essence a condition in which there is insufficient healthy blood cells to convey oxygen to the body.
Outline:
Definition and Description
Inheritance and Genetics
Incidence
Symptoms
Brief Historical Overview
Prognosis and Treatment
From the Paper
"In order for sickle cell anemia to manifest itself the presence of two defective genes ( SS) are needed. In other words, if two parents are the carriers of one sickle hemoglobin gene (S) as well as a single normal cell ( A) then each chills born for these parents will have a "...25% chance of inheriting two defective genes and having sickle cell anemia; a 25% chance of inheriting two normal genes and not having the disease; and a 50% chance of being an unaffected carrier like the parents." (New Hope for People with Sickle Cell Anemia)"
"Individuals who have only one copy of the mutation are said to have sickle cell trait. These people are usually healthy but can transmit the disease to their children. This aspect is clarified by the fact that, "Sickle Cell trait (AS) is an inherited condition in which both hemoglobin A and S are produced in the red blood cells, always more A than S. Sickle cell trait is not a type of sickle cell disease. People with sickle cell trait are generally healthy." (What is Sickle Cell Disease?)"
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Sickle Cell Anemia, 2008.
This paper discusses the dynamics of the condition known as sickle cell anemia.
1,568 words (approx. 6.3 pages), 6 sources, APA, £ 35.95
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Abstract
The paper discusses the molecular genetics of sickle cell anemia and how this disorder alters the red cell's function of homeostasis. The paper relates that the sickle cell gene is spread widely throughout Africa, the Middle East and India and countries in which there are large numbers of African immigrants, including the United States. The paper includes a map (as an appendix) that shows the regions of the world in which the sickle cell gene is most commonly found.
Outline:
Introduction
Molecular Genetics
Metabolic Pathways
Homeostasis
Population Dynamics
Evolution
Conclusion
From the Paper
"There are a number of hereditary anemias, which feature disorders of the structure or synthesis of hemoglobin, deficiencies of enzymes which provide energy to red blood cells or protect the red blood cells from damage, or abnormalities in the proteins found in the cell membranes of red blood cells. Inherited diseases of hemoglobin are the most important, and these are termed hemoglobinopathies; it is into this category that sickle cell anemia falls. Sickle cell anemia has a genetic basis, and was the first genetic disease to be characterized at the molecular level (Ingram, 2004"
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Sickle Cell Anemia, 2004.
An analysis of sickle cell anemia, an inherited blood disorder of defective hemoglobin.
1,065 words (approx. 4.3 pages), 8 sources, MLA, £ 25.95
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Abstract
This paper discusses the inherited blood disorder of sickle cell anemia. The paper presents the statistics of the prevalence of this disorder in the United States and outlines the populations that are most affected by the disease. The paper examines the genotypic and phenotypic expressions of the sickle cell trait. The paper explores the belief that sickle hemoglobin evolved as a protection against malaria.
From the Paper
"Sickle cell anemia is an inherited blood disorder in which hemoglobin is defective (Genetic disease profile: Sickle cell anemia). After hemoglobin molecules give up their oxygen, some cluster together and form long, rod-like structures. These structures cause red blood cells to become stiff and assume a sickle shape that makes it difficult for them to squeeze through small blood vessels. As a result, they stack up and cause blockages that deprive organs and tissues of oxygen-carrying blood. Sickle cell anemia affects millions world wide (Genetic disease profile: Sickle cell anemia). It is the most common among people whose ancestors come from sub-Saharan Africa; Spanish-speaking regions (South America, Cuba, Central America); Saudi Arabia; India; and Mediterranean countries such as Turkey, Greece, and Italy."
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Sickle-Cell Anemia, 2007.
A case study of a 37-year old African-American male with a diagnosed case of sickle-cell anemia.
1,024 words (approx. 4.1 pages), 3 sources, MLA, £ 25.95
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Abstract
This paper is a case study of a 37-year old African-American male with a diagnosed case of sickle-cell anemia who presents himself to the emergency department with changes in sensorium of two days duration. It examines his symptoms, follows his admission procedure and discusses the virulence factors of sickle-cell anemia.
From the Paper
"Upon admission, he was stretcher-borne and noted to be unconscious and unresponsive to verbal commands but localized painful stimuli. Vital signs were: HR 104, RR 25, BP 126/78, T 102oF. Physical examination was significant for nuchal rigidity, Brudzinski's and Kernig's sign. A limited neurological examination revealed no papilledema, bilateral hyperreflexia and dorsifexion of the big toe; no localizing signs were noted. A peripheral line was immediately established and a ceftriaxone loading dose was given followed by vancomycin. A non-contrast cranial CT scan revealed a resolving paranasal sinusitis; no mass lesions or midline shifts were noted. "
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Universal Newborn Hearing Screening, 2002.
An opionion study on the use of the Universal Newborn Hearing Screening tests.
2,150 words (approx. 8.6 pages), 7 sources, £ 55.95
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Abstract
A paper that takes a pervasive view of the concept of Universal Newborn Hearing Screening.
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Newborn Medical Screening Around the World, 2008.
An account of screening tests carried out on newborn babies.
1,683 words (approx. 6.7 pages), 11 sources, MLA, £ 37.95
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Abstract
This paper describes the various tests that are carried out on newborns around the world for early detection of abnormalities, and includes a long list of conditions that can be found. While the author does include evidence of some controversy regarding various screening tests, the overall indication is that such testing can only be beneficial.
From the Paper
"In the United States, newborns have been routinely screened for abnormalities and conditions affecting the infant's overall health, with routine tests such as biotinidase deficiency, congenital adrenal hyperplasia, congenital hearing loss, congenital hypothyroidism, cystic fibrosis, galactosemia, homocystinuria, maple syrup urine disease, MCAD deficiency, PKU, Sickle cell disease, and tyroseinemia. China has taken neonatal screening seriously in recent years, and with assistance from the United States, a "provincial laboratory quality control program has been established and provides oversight for a newborn screening system from blood collection through treatment of patients" (Chen, He, Shen, Wang, Zang, & Zhang 37). Israel has also determined how valuable nationwide neonatal screening is to societal health and in 2006 selected PerkinElmer, Inc., "a global technology leader in Health Sciences and Photonics...to create a comprehensive newborn screening program intended to cover every child born in Israel" (PerkinElmer). This is a definite step in the right direction, as more and more countries follow the lead the United States has had in the realm of neonatal screening."
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