Alzhiemer's Disease

Paper Summary:

This paper examines Alzheimer?s; it?s aetiology and symptoms, in order to question the orthodox and alternative treatments available. It discusses the considered main causes that include zinc, copper, iron and aluminium, as well as including a brief overview of the accepted commonest risk factors. It is concluded by considering and suggesting, that ginkgo biloba is the main contender as the alternative to orthodox medicine in treating and preventing, Alzheimer?s disease.

Outline
Abstract
Introduction
Chapter 1
An Overview of Alzheimer?s Disease ? Definition, Aetiology and Risk Factors
Associated Structural Abnormalities of AD
Beta Amyloid Plaques (BAPs)
Neurofibrillary Tangles
Risk Factors of AD
Chapter 2 ? The Biometals
The ?Normal? role of Zinc
The Paradoxical Role of Zinc
Iron
Copper
Aluminium
Free Radicals and Oxidative Stress
The Cholesterol Theory
Chapter Three ? Ginkgo Biloba
Ginkgo Biloba as an Antioxidant and Preventative
Vitamin ?E? and Other Free Radical Scavengers
Chapter Four - The Role of Orthodox Treatments
Nerve Growth Factor (NGF), One of the Neurotrophic Factors
Selegiline
Oestrogen Replacement Therapy (ERT)
Metal Chelation Therapy
Non-Steroidal Anti-Inflammatory Drugs
Chapter Five ? Conclusion

From the Paper:

"Copper is another essential trace mineral in the human body; it is a constituent of many enzymes and takes part in the absorption of iron and in melanin formation. Lack of copper may result in anaemia and bone changes. Estimated safe and adequate dietary intake is 1.5-3.0 mg/day for adults, and 0.4-0.6 mg/day for infants (Tortora and Grabowski, 2000). Copper plays a crucial role, with cholesterol, in nutrition and normal brain function. Recent evidence indicates that copper and cholesterol may both be important factors in the aetiology of AD. Sparks et al (2003) explains how trace amounts of copper (0.12 ppm) added to water and given to cholesterol-fed rabbits induced BAP accumulation, including senile plaque-like structures in the hippocampus and temporal lobe."

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